Donepezil and concurrent sertraline treatment is associated with increased hippocampal volume in a patient with depression.

To the Editor: Donepezil is a widely used acetylcholinesterase inhibitor that has been shown to slow the progress of cognitive impairment in patients with mild-to-moderate Alzheimer’s disease. We observed a case of refractory depression with a hippocampal volume reduction identical to that commonly observed in earlyonset Alzheimer’s disease. Addition of donepezil in our case led to complete remission of depression that concurred with a robust increase in hippocampal volume. Herein, we report this intriguing case.